ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery
Abstract
The XII-ZOMES Conference (Shenzhen, 2024) showcased advances in PCI complexes—proteasome, COP9 signalosome, and eIF3—which regulate cellular proteostasis through conserved architectures. Presentations covered translation initiation, proteasome assembly, ubiquitin and ubiquitin-like modification regulation, protein quality control mechanisms, and emerging therapeutic technologies including PROTACs and molecular glues for targeted protein degradation.
Fields of Study & Subjects
Ubiquitin and proteasome pathways
Protein Degradation and Inhibitors
Heat shock proteins research
Publication details
- Journal / source
- npj Metabolic Health and Disease
- Volume
- 4
- Issue
- 1
- Publication date
- 27 February 2026
- Language
- EN