A narrative review of impacts of apolipoproteins on atherosclerotic coronary plaques
Abstract
Apolipoproteins are structural components of lipoproteins involved in assembly, enzyme regulation, structural integrity, and receptor binding. Apoprotein(a) forms lipoprotein(a), apolipoprotein A-I drives reverse cholesterol transport, apolipoprotein B reflects atherogenic particle number, and apolipoprotein C-III regulates triglycerides. This review highlights the clinical significance of these apolipoproteins in coronary plaque characteristics detected by imaging modality. Additionally, we summarize the current clinical status of therapeutic agents targeting these apolipoproteins and its future potential.
Fields of Study & Subjects
Cancer
Lipids
and Metabolism
Lipoproteins and Cardiovascular Health
Clusterin in disease pathology
Publication details
- Journal / source
- npj Cardiovascular Health
- Publisher
- Springer Science and Business Media LLC
- Volume
- 3
- Issue
- 1
- Publication date
- 2 February 2026
- Language
- EN