Future directions in all-optical label-free single-molecule sensing

npj Biosensing 2026 Open access

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Authors: Koji Masuda, Reuven Gordon, Philipp Kukura, Christoph Langhammer, Sang-Hyun Oh, Frank Vollmer, Peter Zijlstra
DOI: 10.1038/s44328-025-00069-4
Cited by: 2
References: 151

Abstract

This perspective discusses the future role of all-optical label-free single-molecule sensing. After summarizing the core working principles of the different detection modalities we discuss future research directions in terms of technology development and applications. In terms of future technologies we address research directions in the areas of multi-parametric and interaction free sensors, integration and miniaturization, and advanced data analysis. We further describe potential applications towards probing of protein interactions, DNA and protein sequencing, and molecular diagnostics.

Fields of Study & Subjects

Advanced Fluorescence Microscopy Techniques Photonic and Optical Devices Advanced Biosensing Techniques and Applications

Publication details

Journal / source
npj Biosensing
Publisher
Springer Science and Business Media LLC
Volume
3
Issue
1
Publication date
13 January 2026
Language
EN