Progress and challenges in transplantation of human pluripotent stem cell derived cardiomyocytes for cardiac therapy
Abstract
Myocardial infarction and heart failure remain leading causes of mortality worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a promising approach to regenerating damaged myocardium and restoring cardiac function. This review highlights advancements in hPSC-CM differentiation, scale-up, and clinical-grade manufacturing; delivery approaches; and insights from preclinical and clinical studies. We also examine mechanisms of repair, key challenges and mitigation strategies, and future directions to advance hPSC-CM therapies toward clinical translation.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Congenital heart defects research
Mesenchymal stem cell research
Publication details
- Journal / source
- npj Biomedical Innovations.
- Publisher
- Springer Science and Business Media LLC
- Volume
- 3
- Issue
- 1
- Pages
- 2–2
- Publication date
- 7 January 2026
- Language
- EN