From organoid culture to manufacturing: technologies for reproducible and scalable organoid production

npj Biomedical Innovations. 2026 Open access

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Authors: Dohui Kim, Dohui Kim, Jaeseung Youn, Juhyeok Kim, Jeongmin Lee, Jangwon Yoon, Dong Sung Kim, Dong Sung Kim
DOI: 10.1038/s44385-025-00054-6
Cited by: 27
References: 193

Abstract

In this review, we systematically categorize diverse organoid engineering strategies-including cellular programming, material engineering, and platform- or system-level innovations-according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.

Fields of Study & Subjects

3D Printing in Biomedical Research Cancer Cells and Metastasis Pluripotent Stem Cells Research

Publication details

Journal / source
npj Biomedical Innovations.
Publisher
Springer Science and Business Media LLC
Volume
3
Issue
1
Publication date
2 February 2026
Language
EN