Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis

npj Biomedical Innovations. 2026 Open access

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Authors: Muhammad Farooq Rai, Christine T. N. Pham, Kirk Kohwa Hou, Samuel A. Wickline, Hua Pan
DOI: 10.1038/s44385-026-00068-8
Cited by: 0
References: 107

Abstract

Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics-siRNA, miRNA, and mRNA-as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.

Fields of Study & Subjects

Osteoarthritis Treatment and Mechanisms RNA Interference and Gene Delivery Bone Metabolism and Diseases

Publication details

Journal / source
npj Biomedical Innovations.
Volume
3
Issue
1
Pages
17–17
Publication date
27 February 2026
Language
EN