Peptide-based targeted drug delivery strategies for osteoarthritis treatment
Abstract
Peptide-based strategies offer promising solutions to overcome the complex, multi-tissue barriers of osteoarthritis. Their tunability, specificity, and versatility enable targeted drug delivery to cartilage, synovium, and subchondral bone, while some therapeutic peptides provide intrinsic anti-inflammatory, regenerative, or analgesic effects. Advances in peptide design, stability engineering, and in silico screening, alongside emerging human joint-on-chip models, are accelerating the development of targeted, stable, multi-tissue OA therapies.
Fields of Study & Subjects
Osteoarthritis Treatment and Mechanisms
Bone Tissue Engineering Materials
Supramolecular Self-Assembly in Materials
Publication details
- Journal / source
- npj Biomedical Innovations.
- Publisher
- Springer Science and Business Media LLC
- Volume
- 3
- Issue
- 1
- Publication date
- 9 April 2026
- Language
- EN