Advancements in RNA-based therapies from bench to bedside

npj Drug Discovery. 2026 Open access

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Authors: Amrita Singh, Muktika Tekade, Sreeharsha Nagaraja, Azad Bharti, Rakesh Kumar Tekade
DOI: 10.1038/s44386-025-00037-y
Cited by: 16
References: 248

Abstract

RNA research has advanced rapidly, becoming a key component of modern therapeutics. This review outlines key milestones and innovations from antisense oligonucleotides and RNA interference to mRNA therapies and aptamers that have enabled targeted treatments for diverse diseases. The success of COVID-19 mRNA vaccines highlighted the remarkable clinical potential of RNA-based technologies. Emphasis is placed on delivery technologies, landmark approvals, and ongoing trials shaping the future of RNA-based medicine.

Fields of Study & Subjects

RNA Interference and Gene Delivery MicroRNA in disease regulation Advanced biosensing and bioanalysis techniques

Publication details

Journal / source
npj Drug Discovery.
Publisher
Springer Science and Business Media LLC
Volume
3
Issue
1
Publication date
9 February 2026
Language
EN