The brain side of human-AI interactions in the long-term: the “3R principle”
Abstract
Neuroplasticity is shaped by how humans interact with AI. We argue that passive, uncritical, reliance on AI may weaken activity-dependent brain plasticity and erode cognition, whereas active co-creation can sustain or enhance it. Drawing on plasticity rules and ethical considerations, we propose the 3R principle—Results, Responses, Responsibility—as a preventive framework for cognitive hygiene, urging education towards AI use to preserve agency, meaning-making, and long-term brain health.
Fields of Study & Subjects
Neuroethics
Human Enhancement
Biomedical Innovations
Artificial Intelligence in Healthcare and Education
Embodied and Extended Cognition
Publication details
- Journal / source
- npj Artificial Intelligence
- Publisher
- Springer Science and Business Media LLC
- Volume
- 2
- Issue
- 1
- Publication date
- 27 January 2026
- Language
- EN