Dysregulated neuronal mRNA transport and translation in FTD/ALS
Abstract
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal, co-occurring neurodegenerative disorders. Dysregulation of mRNA metabolism, transport, and local translation is a significant mechanism contributing to FTD/ALS. Here, we review the processes of neuronal RNA transport and translation, their disruption in FTD/ALS, and mechanistic interplay between the two. Finally, we discuss current progress targeting transport and translation defects and identify potential future directions for therapeutic development.
Fields of Study & Subjects
Amyotrophic Lateral Sclerosis Research
RNA Research and Splicing
Neurogenetic and Muscular Disorders Research
Publication details
- Journal / source
- npj Dementia
- Publisher
- Springer Science and Business Media LLC
- Volume
- 2
- Issue
- 1
- Pages
- 56–56
- Publication date
- 8 July 2026
- Language
- EN