Clinical infusion bypasses physiological barriers to directly deliver microplastics into human circulation

npj Emerging Contaminants 2026 Open access

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Authors: X Zhao, Yutong Duan, Liyan Deng, Huaidong Du, Sheng Chen, Yueping Wang, Chunli Wan, Yudong Song, Xiaowei Wang, Changyong Wu
DOI: 10.1038/s44454-026-00044-2
Cited by: 1
References: 26

Abstract

Intravenous infusion bypasses physiological barriers, directly introducing microplastics (MPs) into the bloodstream. Cleanroom simulations revealed MPs concentrations of 211 ± 34 (0.9% NaCl) and 179 ± 28 MPs/L (5% glucose), mostly < 20 µm in size, plus with 4–5 µg/L nanoplastics. Predominantly polyamide and polyvinyl alcohol, matching infusion materials. A 5-day infusion delivers > 1000 particles - equivalent to months of inhalation/ingestion exposure. This overlooked medical route necessitates safer materials and regulation.

Fields of Study & Subjects

Microplastics and Plastic Pollution Nanoparticles: synthesis and applications Graphene and Nanomaterials Applications

Publication details

Journal / source
npj Emerging Contaminants
Publisher
Springer Science and Business Media LLC
Volume
2
Issue
1
Publication date
3 July 2026
Language
EN