Quantification of buparlisib in human liver microsomes employing an ultra-fast, sensitive UPLC-MS/MS method: in vitro and in silico metabolic stability evaluation

The Analyst 2026

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Authors: Mohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi
DOI: 10.1039/d5an01155h
Cited by: 1
References: 54

Abstract

tools (ADME, DEREK and WhichP450) provide a resource-effective strategy for preliminary metabolic screening and advancing new therapeutic development aimed at enhancing metabolic stability of new BLB derivatives.

Fields of Study & Subjects

Metabolomics and Mass Spectrometry Studies Drug Transport and Resistance Mechanisms Computational Drug Discovery Methods

Publication details

Journal / source
The Analyst
Publisher
Royal Society of Chemistry (RSC)
Volume
151
Issue
4
Pages
1058–1070
Publication date
1 January 2026
Language
EN