Electrochemical evaluation of plant extracts as potential antidotes for acetaminophen poisoning

The Analyst 2026

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Authors: Rahim Babereh, Hassan Shayani‐Jam, Mohammad Reza Yaftian, Bahman Farajmand, Mohammad Hassan Moeini, Shadi Moeinifar
DOI: 10.1039/d5an01322d
Cited by: 0
References: 55

Abstract

, indicating their potential as NAPQI scavengers. These findings highlight the varying scavenging capacities of plant extracts. The high reactivity of pomegranate peel extract with NAPQI, driven by an EC' mechanism, suggests its potential as a cost-effective, natural antidote for acetaminophen poisoning. This study introduces a novel electroanalytical approach for antidote development, elucidating interaction mechanisms between plant extracts and NAPQI. Unlike traditional methods, this electrochemical strategy offers precise, rapid assessment of antidote efficacy, providing a scalable framework for evaluating natural compounds to mitigate acetaminophen-induced liver damage.

Fields of Study & Subjects

Drug-Induced Hepatotoxicity and Protection Electrochemical sensors and biosensors Electrochemical Analysis and Applications

Publication details

Journal / source
The Analyst
Volume
151
Issue
10
Pages
2927–2934
Publication date
1 January 2026
Language
EN