A highly sensitive LC-MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study

Analytical Methods 2026

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Authors: Dandan Pan, L L Chen, Haonan Luo, Haiyan Liu, W. Chen, Zhenzhou Jiang, Zhen Qiu, Nan Zhou, Yequan Zhou, Qiujin Xu, Tao Wang, Qian Lu
+1 more Tingting Yang
DOI: 10.1039/d5ay01136a
Cited by: 2
References: 23

Abstract

449.30 → 252.20 for the IS. The method demonstrated excellent linearity, stability, accuracy, precision, recovery, and a non-significant matrix effect within the validated range. A one-compartment model with rapid absorption and distribution, quicker elimination, and clear tissue distribution was demonstrated by the mean blood concentration-time curve of AB-38b in rat plasma. The liver tissue contained high levels of AB-38b, with no evidence of tissue accumulation observed. These findings offer a reference for further research into the pharmacological mechanisms and potential therapeutic applications of AB-38b in metabolically related diseases, especially DKD.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Advanced Glycation End Products research Peroxisome Proliferator-Activated Receptors

Publication details

Journal / source
Analytical Methods
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
4
Pages
800–811
Publication date
1 January 2026
Language
EN