Dual-mode CRISPR/Cas12a-mediated alkaline phosphatase detection (CAD) biosensor

Analytical Methods 2026

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Authors: Daqi Chen, Baian Zhu, Zhou yachunyue, Zhezhi Fang, Zhuobin Zhu, Chaozhan Chen, Teng Shen
DOI: 10.1039/d5ay01195g
Cited by: 0
References: 33

Abstract

, offering the potential to effectively differentiate pathological samples from normal physiological levels with an appropriate dilution factor for clinical samples. Our dual-mode biosensing strategy not only enables high-precision quantitative analysis in clinical settings but also facilitates rapid qualitative detection under resource-limited conditions, thus offering significant potential for early disease diagnosis and long-term therapeutic monitoring.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques Biosensors and Analytical Detection CRISPR and Genetic Engineering

Publication details

Journal / source
Analytical Methods
Volume
18
Issue
6
Pages
1239–1247
Publication date
1 January 2026
Language
EN