Tyrosinase detection via enzyme-triggered structural transformation of a ratiometric fluorescent probe

Analytical Methods 2026

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Authors: Minwoo Han, Haemin Choi, Juyeon Cha, Young-Sun Kim, Seoung Ho Lee
DOI: 10.1039/d5ay01258a
Cited by: 1
References: 44

Abstract

Tyrosinase is a key biomarker in melanoma, emphasizing the need for reliable detection. Here, we developed a ratiometric fluorescent probe that undergoes enzyme-triggered structural transformation, evidenced by HPLC and spectral changes. It enables sensitive analysis, inhibitor evaluation, and detection in spiked human serum, demonstrating potential for diagnostic applications.

Fields of Study & Subjects

melanin and skin pigmentation Melanoma and MAPK Pathways Cutaneous Melanoma Detection and Management

Publication details

Journal / source
Analytical Methods
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
2
Pages
287–292
Publication date
1 January 2026
Language
EN