Validation of an RP-HPLC method for simultaneously quantifying three UV filters encapsulated into nanostructured lipid carriers
Abstract
), and compliance with the ICH guidelines. The method enabled the accurate and precise determination of filter extracted content, based on the extraction method, and encapsulation efficiency, supporting formulation optimization and industrial scalability by identifying a pool of interchangeable prototypes. Encapsulation efficiency of the UV-filters as the main response evaluated, which was interpreted through the critical quality attributes (CQAs) of values above 70%. Hence, the present study addresses a critical gap in the analytical methodologies for emerging nanoformulation technologies.
Fields of Study & Subjects
Analytical Methods in Pharmaceuticals
Advancements in Transdermal Drug Delivery
Analytical Chemistry and Chromatography
Publication details
- Journal / source
- Analytical Methods
- Volume
- 18
- Issue
- 8
- Pages
- 1732–1743
- Publication date
- 1 January 2026
- Language
- EN