Precision detection of rifampicin-resistant rpoB _L378R mutation in Mycobacterium tuberculosis with CRISPR-Cas12a

Analytical Methods 2026

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Authors: Yuma Yang, Yuma Yang, Li Yang, Hao Ma, Shuming Zhang, Yue Zhu, Sihan Zhang, Xiting Lin, Haitao La, Xiumin Gu, Jing Ma, Sihao Zhao
+5 more Yinfeng Yang, Yinfeng Yang, Hetian Lei, Yanhui Yang, Yanhui Yang
DOI: 10.1039/d5ay01718a
Cited by: 1
References: 43

Abstract

Novel RPA-CRISPR-Cas12a assay detects the rifampicin-resistant rpoB _L378R mutation.

Fields of Study & Subjects

CRISPR and Genetic Engineering Tuberculosis Research and Epidemiology Immunodeficiency and Autoimmune Disorders

Publication details

Journal / source
Analytical Methods
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
7
Pages
1442–1453
Publication date
1 January 2026
Language
EN