Comparison of biological materials to assess their suitability for Raman spectroscopic detection of chronic myeloid leukemia

Analytical Methods 2026

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Authors: Sreeparna Nath, Arti R. Hole, Bhausaheb Pandurang Bagal, Hemanth Noothalapati, Rukmini B. Govekar, C. Murali Krishna
DOI: 10.1039/d5ay01729g
Cited by: 0
References: 27

Abstract

PC-LDA were 70.73% (cells), 86.36% (plasma), and 88.64% (serum), with data fusion across sample types enhancing accuracy to 95.12-100%. Notably, MCR identified discriminative spectral components in plasma (component 6) and serum (component 5). These findings demonstrate the capacity of RS to differentiate CML from healthy states across multiple biological samples and identify serum as the most suitable material for future RS-based clinical diagnostics. This study provides a methodological foundation for future work toward developing mechanism-independent RS platforms for clinical monitoring in CML.

Fields of Study & Subjects

Spectroscopy Techniques in Biomedical and Chemical Research Spectroscopy and Chemometric Analyses Metabolomics and Mass Spectrometry Studies

Publication details

Journal / source
Analytical Methods
Volume
18
Issue
8
Pages
1654–1666
Publication date
1 January 2026
Language
EN