Multi-detector frit-inlet asymmetric flow field-flow fractionation method development for nanoparticle mixtures: deeper analysis beyond ISO quality standards

Analytical Methods 2026 Open access

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Authors: Rand Abdulrahman, Panida Punnabhum, Lisa van den Driest, Nicholas J. W. Rattray, Robin Bruno Capomaccio, Kevin Edward Treacher, Yvonne Perrie, Zahra Rattray
DOI: 10.1039/d5ay01758k
Cited by: 0
References: 74

Abstract

> 0.95 and RMSE < 0.009). In summary, implementing the FI-AF4-UV-MALS-DLS protocol provided successful separation of LNPs from protein-containing media with additional analytical approaches not previously described by ISO guidelines. Collecting robust and reproducible information on LNP attributes is key to the several phases of drug development that ideally transform a drug in the pre-clinical phase, from bench-to-bedside.

Fields of Study & Subjects

Field-Flow Fractionation Techniques Nanoparticle-Based Drug Delivery Microfluidic and Capillary Electrophoresis Applications

Publication details

Journal / source
Analytical Methods
Volume
18
Issue
8
Pages
1637–1653
Publication date
1 January 2026
Language
EN