A hydrophilic interaction UPLC-MS/MS quantitative method for the quantification of saracatinib in the human liver microsome matrix and its application in in vitro metabolic stability assessment
Abstract
The hydrophilic interaction UPLC-MS/MS method was used for the quantification of saracatinib in HLMs. Small changes to the N -methyl piperazine in drug design might improve the metabolic stability of new derivatives compared with that of saracatinib.
Fields of Study & Subjects
Chronic Myeloid Leukemia Treatments
Metabolomics and Mass Spectrometry Studies
Lung Cancer Treatments and Mutations
Publication details
- Journal / source
- Analytical Methods
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 18
- Issue
- 8
- Pages
- 1695–1708
- Publication date
- 1 January 2026
- Language
- EN