Early diagnosis of fibrogenic remodeling in idiopathic pulmonary fibrosis by targeting matrix metalloproteinase-2 with CT imaging
Abstract
, MSNPs demonstrated high sensitivity and specificity for MMP2, showing significant intracellular accumulation upon activation. In a bleomycin-induced mouse model of IPF, CT imaging with MSNPs revealed a substantial increase in signal intensity at lesion sites as early as days 5 and 10 post-induction. This increase correlated with fibrosis severity, as confirmed by histopathology, elevated MMP2 expression, and measured nanoprobe accumulation in lung tissues. Collectively, this MMP2-targeted CT imaging strategy represents a promising non-invasive method for the detection of fibrogenic remodeling in IPF.
Fields of Study & Subjects
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Pulmonary Hypertension Research and Treatments
Peptidase Inhibition and Analysis
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 10
- Pages
- 2718–2729
- Publication date
- 1 January 2026
- Language
- EN