Silk fibroin scaffolds loaded with growth factors can reverse liver fibrosis

Biomaterials Science 2026 Open access

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Authors: Jingyi Wang, Zhanbo Wang, Shuo Zhao, Daxu Zhang, Jingjing Hu, Weilong Li, Xiaonan Shi, Shujun Ye, Xiaojiao Liu, Yaopeng Zhang, Li Yan
DOI: 10.1039/d5bm01314c
Cited by: 0
References: 33

Abstract

< 0.05). Immunohistochemistry further revealed neovascularization and bile duct formation by day 14. Transcriptomic profiling showed upregulation of bile duct development pathways and downregulation of inflammatory signaling. Quantitative PCR confirmed increased expression of bile secretion genes (FXR, OAT) and decreased expression of NF-κB pathway genes (TRAF2, Bax). These findings highlight the RSF/HGF/FGF-4 scaffold as a promising cell-free strategy for promoting functional liver regeneration and reversing chronic liver fibrosis.

Fields of Study & Subjects

Silk-based biomaterials and applications Tissue Engineering and Regenerative Medicine Liver physiology and pathology

Publication details

Journal / source
Biomaterials Science
Volume
14
Issue
5
Pages
1235–1248
Publication date
1 January 2026
Language
EN