Norharmane-loaded bacterial cytoplasmic membrane-coated nanoparticles synergistically enhance polymyxin B against Pseudomonas aeruginosa infections by disrupting biofilms
Abstract
, intraperitoneal administration of Mφ-PLGA-NOR combined with PMB achieved a 2-log reduction in bacterial lung burden. This study underscores the promise of bacterial plasma membrane-based pathogen-mimetic nanoplatforms in potentiating the efficacy of antibiotic adjuvants in conjunction with biofilm-penetrating strategies.
Fields of Study & Subjects
Antibiotic Resistance in Bacteria
Bacterial biofilms and quorum sensing
Antimicrobial agents and applications
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 4
- Pages
- 1009–1022
- Publication date
- 1 January 2026
- Language
- EN