Clickable polyamidosaccharides: accessing bottlebrush inspired hyaluronic acid glycopolymers for CD44 targeting of breast cancer cells

Biomaterials Science 2026 Open access

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Authors: Kaitlynn A. Sockett, Madeline K. Loffredo, Christian D. DeMoya, Zoe G. Garman, Mark W. Grinstaff
DOI: 10.1039/d5bm01613d
Cited by: 1
References: 67

Abstract

a strain-promoted azide-alkyne cycloaddition. Among these homopolymers and copolymers, two of the polymers bearing the highest HA disaccharide conjugation bind CD44 with nanomolar affinity. Assays using a rhodamine-labelled polymer reveal a positive relationship between cellular internalization and CD44 expression levels in breast cancer cells. Conjugation of paclitaxel to the polymer enhances paclitaxel potency in CD44-expressing cancer cells compared to free paclitaxel.

Fields of Study & Subjects

Proteoglycans and glycosaminoglycans research Hydrogels: synthesis properties applications Seaweed-derived Bioactive Compounds

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
6
Pages
1530–1543
Publication date
1 January 2026
Language
EN