Chemical and enzymatic strategies for the synthesis, ligation, assembly and emerging applications of DNA nanostructures

Biomaterials Science 2026

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Authors: Yichen Wang, Yuyi Wang, Jialin Wu, Pengyuan Xu, Hongbo Cui, Peng Guo, Han Cao, Weigang Chen, Guijian Guan, Ming‐Yong Han
DOI: 10.1039/d5bm01632k
Cited by: 1
References: 139

Abstract

, including drug delivery, bioimaging, molecular machines, and therapeutic interventions. Finally, we highlight emerging frontiers of DNA nanotechnology, particularly its integration into nanoelectronics and its transformative potential as a medium for digital data storage. By addressing recent advances, current challenges, and future perspectives, this review underscores the pivotal role of chemical and enzymatic techniques in advancing DNA nanotechnology as a foundational platform for next-generation biomedical, materials, and information technologies.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques DNA and Nucleic Acid Chemistry Supramolecular Chemistry and Complexes

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
3
Pages
760–779
Publication date
1 January 2026
Language
EN