Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol–disulfide exchange

Biomaterials Science 2026 Open access

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Authors: Dandan Zhu, Huiling Zhu, Yaoyun Yu, Junyue Zheng, Xianhui Lin, Huimin Cheng, Aoxue Mei, Ming Chen, Yun Li, Haijuan Dong, Jiehua Zhou, Juan LIU
+1 more Xiaoxuan Liu
DOI: 10.1039/d5bm01643f
Cited by: 3
References: 38

Abstract

achieved substantial reductions in tumor growth and PLK1 expression while exhibiting minimal systemic toxicity. This study highlights a synergistic approach utilizing bola-amphiphilic peptide dendrimers for tumor-specific and cytosolic siRNA delivery, leveraging membrane-thiol interactions and intracellular GSH-triggered siRNA release.

Fields of Study & Subjects

RNA Interference and Gene Delivery Dendrimers and Hyperbranched Polymers Sulfur Compounds in Biology

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
4
Pages
1073–1085
Publication date
1 January 2026
Language
EN