A multiphasic core–shell flurbiprofen and ciprofloxacin-loaded nanofibrous dressing cures infected burns via dual control of infection and inflammatory response
Abstract
in BALB/c mice and this group showed significant healing on day 18 compared to the untreated group. Bacterial growth inhibition, re-epithelization, neovascularization, collagen reappearance, and orientation were determined using the colony count method, and H&E, MT, and VG staining, respectively. Also, evidence from IHC staining confirmed secondary skin organ formation. The PCL-CS-based dual drug delivery system provides synergistic enhanced therapeutic efficacy and could be a solution to the simultaneous challenges in burn wounds.
Fields of Study & Subjects
Wound Healing and Treatments
Electrospun Nanofibers in Biomedical Applications
Graphene and Nanomaterials Applications
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 7
- Pages
- 1806–1829
- Publication date
- 1 January 2026
- Language
- EN