Silica-coated papillomavirus-based nanoparticles: a shielded scaffold for HIV-1 vaccines

Biomaterials Science 2026 Open access

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Authors: Yu Wang, Kathrin Kostka-Wirtz, Nils Bartelsen, Kateryna Loza, Christoph Weingärtner, Philipp Arnold, Dominik Damm, Klaus Überla, Matthias Epple, Vladimir Temchura
DOI: 10.1039/d5bm01792k
Cited by: 1
References: 53

Abstract

, the silica coating effectively masked L1-specific B cell epitopes, reduced anti-scaffold IgG responses and enhanced Env-specific antibody production in mice pre-immunized against HPV. This synthetic strategy offers a versatile platform for overcoming scaffold-directed immunity in nanoparticle vaccines.

Fields of Study & Subjects

Immunotherapy and Immune Responses Advanced Drug Delivery Systems HIV Research and Treatment

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
12
Pages
3281–3294
Publication date
1 January 2026
Language
EN