pH-responsive polydopamine-shelled 3D-printed chitosan/collagen hydrogel integrating exosomes and an enzyme/peptide cascade for diabetic wound healing
Abstract
studies-including diabetic rat skin defects, C57 infectious dermatitis, and rabbit full-thickness ear wound models-demonstrated that the G3 core-shell scaffold significantly accelerated wound closure, reduced bacterial load, and promoted ordered collagen deposition, re-epithelialization, and skin appendage regeneration. This study provides an intelligent 3D-printed hydrogel dressing capable of multi-target synergistic regulation of the wound microenvironment, offering a novel strategy with application potential for treating complex diabetic wounds.
Fields of Study & Subjects
Wound Healing and Treatments
Polymer Surface Interaction Studies
Hydrogels: synthesis
properties
applications
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 5
- Pages
- 1332–1355
- Publication date
- 1 January 2026
- Language
- EN