Modeling a hypoxia-integrated glioblastoma microenvironment to mimic tumor heterogeneity and chemoresistance
Abstract
, reflecting clinically relevant therapy resistance. These findings show the ability of the model to mimic key properties of the GBM microenvironment at both phenotypic and molecular levels and offer a physiologically relevant platform to study GBM biology and evaluate therapeutic responses.
Fields of Study & Subjects
Cancer
Hypoxia
and Metabolism
Glioma Diagnosis and Treatment
Mathematical Biology Tumor Growth
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 15
- Pages
- 3963–3981
- Publication date
- 1 January 2026
- Language
- EN