Investigation of nanoscale topography and biomechanical tuning of PDMS substrates to enhance cardiomyocyte differentiation from human induced pluripotent stem cells

Biomaterials Science 2026

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Authors: Fatemeh Etezadi, Mohammad Ali Shokrgozar, Shahin Bonakdar, Kentaro Hayashi, Daniel M. Packwood, Motomu Tanaka, Kouichi Hasegawa
DOI: 10.1039/d5bm01840d
Cited by: 0
References: 52

Abstract

PDMS is still the most widely used biomaterial for bioengineering studies, which can mimic the tissue stiffness and micro/nanostructure to improve the generation and investigation of iCM differentiation from hiPSCs.

Fields of Study & Subjects

Cellular Mechanics and Interactions Pluripotent Stem Cells Research Tissue Engineering and Regenerative Medicine

Publication details

Journal / source
Biomaterials Science
Volume
14
Issue
5
Pages
1309–1322
Publication date
1 January 2026
Language
EN