Nanocellulose with dual carboxy and aldehyde functionality: a modular platform for hydrogel formation and sustained drug release

Biomaterials Science 2026 Open access

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Authors: Emanuela Bua, Chiara Spanu, Giovanni Inzalaco, Martina Zangari, Luca Sartorelli, Letizia Sambri, Elisabetta Venuti, Tommaso Salzillo, Mauro Comes Franchini, M Chiariello, Erica Locatelli
DOI: 10.1039/d5bm01841b
Cited by: 2
References: 25

Abstract

biocompatibility. As a proof-of-concept, the chemotherapeutic agent doxorubicin was incorporated into selected hydrogel formulations, showing a sustained release over three weeks without a burst effect. These findings highlight the potential of bifunctional CNCs as a modular and customizable platform for the development of injectable hydrogels for prolonged local drug delivery.

Fields of Study & Subjects

Advanced Cellulose Research Studies Hydrogels: synthesis properties applications Polysaccharides and Plant Cell Walls

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
8
Pages
2027–2038
Publication date
1 January 2026
Language
EN