Synergistic pharmacotherapy for epilepsy: NPY (3–36)-modified ZIF-90 nanoparticles co-delivering GW2580
Abstract
. The BBB permeability and its effects on neuroinflammation and neuronal excitability were assessed. The therapeutic efficacy of NPY@ZIF-RG was explored using immunohistochemistry, quantitative real-time polymerase chain reaction, and behavioral tests in a mouse model of kainic acid-induced acute epilepsy. The results indicated that NPY@ZIF-RG exhibited excellent biocompatibility and efficient BBB penetration. Furthermore, it exerted beneficial therapeutic effects by inhibiting microglia-mediated inflammation and reducing excitatory glutamate release. NPY@ZIF-RG alleviated hippocampal neuronal loss and cognitive dysfunction by co-delivering GW2580 and NPY (3-36), which exerted synergistic neuroprotective and anti-inflammatory effects. This study provides a promising nanocomposite drug-delivery system for the treatment of epilepsy.
Fields of Study & Subjects
Metal-Organic Frameworks: Synthesis and Applications
Nanoparticle-Based Drug Delivery
Graphene and Nanomaterials Applications
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 5
- Pages
- 1262–1275
- Publication date
- 1 January 2026
- Language
- EN