Enhanced corneal retention of hyaluronic acid via a metabolic glycoengineering-based in vivo bioorthogonal reaction

Biomaterials Science 2026

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Authors: Buwei Hu, Hui Wang, Chenli Ji, Xuehan Xu, Luyi Wang, Tingting Cao, Menghua Gao, Yanjun Zhao, Bin Wang, Wenjing Xuan, Jianjun Cheng
DOI: 10.1039/d5bm01898f
Cited by: 2
References: 49

Abstract

bioorthogonal reaction that enhanced HA retention (up to 6 h) by 2.5-fold compared to the control without AAM pretreatment. The prolonged corneal retention enhanced the therapeutic efficacy at a reduced dosing frequency. This approach offers a clinically translatable strategy to improve the efficacy of topical HA-based therapies for ocular diseases.

Fields of Study & Subjects

Proteoglycans and glycosaminoglycans research Ocular Surface and Contact Lens Ocular Infections and Treatments

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
9
Pages
2372–2383
Publication date
1 January 2026
Language
EN