Repression of bacterial gene expression by antivitamin B 12 binding to a cobalamin riboswitch

RSC Chemical Biology 2026 Open access

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Authors: Florian J. Widner, Naziyat Khan, Evelyne C. Deery, Martin J. Warren, Michiko E. Taga, Bernhard Kräutler
DOI: 10.1039/d5cb00308c
Cited by: 1
References: 51

Abstract

Coenzyme B 12 and its Rh-analogue, the antivitamin B 12 AdoRhbl, bind both the btuB -riboswitch with exceptional affinity and inhibit expression of the bacterial B 12 uptake protein BtuB , signifying AdoRhbl's high potential as multifunctional antibiotic.

Fields of Study & Subjects

Porphyrin Metabolism and Disorders Folate and B Vitamins Research Bacterial Genetics and Biotechnology

Publication details

Journal / source
RSC Chemical Biology
Publisher
Royal Society of Chemistry (RSC)
Volume
7
Issue
3
Pages
498–504
Publication date
1 January 2026
Language
EN