Base-catalyzed switchable reactivity of N -acyl-α-aminonitriles: oxidative decyanation to imides and hydrolysis to amides in batch and flow conditions

Chemical Communications 2026 Open access

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Authors: Vikraman Ganesh Moorthi, Vijay Thavasianandam Seenivasan, Sharmila Nokku, Aron Manick Joel, Wei‐Yu Lin, Gopal Chandru Senadi
DOI: 10.1039/d5cc05918f
Cited by: 0
References: 58

Abstract

O-DMSO conditions afford amides. The protocol shows good scalability and broad functional-group tolerance, and enables late-stage modification of pharmaceutically relevant, ibuprofen-derived substrates; mechanistic studies suggest oxidative decyanation and nitrile hydrolysis pathways for imides and amides, respectively.

Fields of Study & Subjects

Advanced Synthetic Organic Chemistry Chemical Reaction Mechanisms Chemical Synthesis and Reactions

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
19
Pages
5477–5481
Publication date
1 January 2026
Language
EN