The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides

Chemical Communications 2026

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Authors: Xuefei Jing, Jen Suh, Joshua W. C. Maxwell, Karishma Patel, Alexander R. Norman, Xavier J. Reid, Chandrika N. Deshpande, J. Low, Richard J. Payne, Toby Passioura, Joel P. Mackay
DOI: 10.1039/d5cc06167a
Cited by: 0
References: 44

Abstract

The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.

Fields of Study & Subjects

Chemical Synthesis and Analysis Monoclonal and Polyclonal Antibodies Research Biochemical and Structural Characterization

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
13
Pages
4028–4031
Publication date
1 January 2026
Language
EN