Benchtop NMR signal enhancement of metabolites in urine extract using SABRE

Chemical Communications 2026 Open access

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Authors: Simon Fleischer, Jing Yang, Kerti Ausmees, Indrek Reile, Neil MacKinnon, Jan G. Korvink, Sören Lehmkuhl
DOI: 10.1039/d5cc06186e
Cited by: 2
References: 40

Abstract

Metabolites in a urine extract are signal-enhanced by SABRE hyperpolarization and detected using a benchtop NMR spectrometer. Quantification by standard addition is demonstrated for endogenic urinary nicotinamide (vitamin B3). Even higher sensitivity is achieved in an automated setup for multi-scan SABRE experiments. This hyperpolarization scheme is able to expedite biomarker detection and quantification, while maintaining low infrastructure requirements.

Fields of Study & Subjects

Advanced NMR Techniques and Applications Metabolomics and Mass Spectrometry Studies NMR spectroscopy and applications

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
10
Pages
3342–3346
Publication date
1 January 2026
Language
EN