Metal- and photocatalyst-free CF 3 -modification of N -containing fusion skeletons in photo-flow chemistry

Chemical Communications 2026

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Authors: Ting Lv, Chenxi Gu, Yuchen Zhu, Yunfeng He, Wen Lin, Wenjian Wang, Xingyi Zhu, Jianjun Li
DOI: 10.1039/d5cc06603d
Cited by: 2
References: 33

Abstract

Herein, we present an external photocatalyst-free protocol for the synthesis of trifluoromethylated, nitrogen-containing fused-ring scaffolds under photo-flow conditions. Based on a series of mechanistic studies, we propose two plausible reaction pathways that highlight the interaction between the substrate and the trifluoromethylating reagent.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Innovative Microfluidic and Catalytic Techniques Innovation

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
8
Pages
2629–2632
Publication date
1 January 2026
Language
EN