Dual pharmacokinetic modifier strategy for synergistically enhanced tumor accumulation of PSMA-targeting radioligand

Chemical Communications 2026 Open access

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Authors: Takuma Hasegawa, Kazuma Nakashima, Hiroyuki Watanabe, Masahiro Ono
DOI: 10.1039/d5cc06620d
Cited by: 2
References: 27

Abstract

Herein, we report a novel molecular design strategy that introduces two distinct pharmacokinetic modifiers into a single radioligand to achieve the synergistic enhancement of tumor accumulation. We newly designed a small-molecule-based radioligand, which contains both a positively charged unit and an albumin binder, and demonstrated its enhanced tumor accumulation.

Fields of Study & Subjects

Prostate Cancer Treatment and Research Nanoplatforms for cancer theranostics Advanced Breast Cancer Therapies

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
16
Pages
4851–4854
Publication date
1 January 2026
Language
EN