Novel radiation-activated N -oxide prodrugs for highly selective and synergistic tumor therapy to promote DNA damage and the ATM/ATR pathway

Chemical Communications 2026

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Authors: Dongliang Ji, Jian Chen, Yifan Ma, Ningning Luo, Yangyang Jiang, Rong Cao, Dongwei Liu, Yunhao Zhang, Lei Wang, Tao Yang, Yong Ling
DOI: 10.1039/d5cc06629h
Cited by: 2
References: 26

Abstract

) to enable synergistic and highly selective chemo-radiotherapy. NOS exerts its inhibitory effect by inducing DNA damage and activating the ATM/ATR pathway, effectively achieving a 90.5% tumor inhibition rate in a liver cancer xenograft model.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Radiation Therapy and Dosimetry Cancer therapeutics and mechanisms

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
13
Pages
4054–4058
Publication date
1 January 2026
Language
EN