High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry

Chemical Communications 2026 Open access

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Authors: Jie Li, Nicolás M. Morato, Bo Hao, Ainslie Chen, Lucile Jouffroy, Ho Kim, Zhicai Shi, Karel Goossens, Iulia I. Strambeanu, R. Graham Cooks
DOI: 10.1039/d5cc06641g
Cited by: 2
References: 49

Abstract

Rapid chiral analysis is important for high-throughput experimentation in drug development. Here, we implement the so-called "kinetic method" on an automated DESI-MS platform for the fast and separation-free enantiomeric analysis (0.2 min per sample) of a variety of chiral molecules directly from mixtures.

Fields of Study & Subjects

Mass Spectrometry Techniques and Applications Metabolomics and Mass Spectrometry Studies Analytical Chemistry and Chromatography

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
12
Pages
3839–3842
Publication date
1 January 2026
Language
EN