Development of covalent inhibitors for bacterial histidine kinases

Chemical Communications 2026 Open access

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Authors: Patricia Rodríguez, Conrad A. Fihn, Manibarsha Goswami, Erin E. Carlson
DOI: 10.1039/d5cc06657c
Cited by: 0
References: 36

Abstract

A scaffold previously discovered to inhibit bacterial histidine kinases was derivatized with a sulfonyl fluoride to promote covalent association with these proteins.

Fields of Study & Subjects

Bacterial Genetics and Biotechnology Click Chemistry and Applications Biochemical and Structural Characterization

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
19
Pages
5482–5486
Publication date
1 January 2026
Language
EN