Chemoselective synthesis of α-fluoromethyl amides via the controlled addition of LiCH 2 F to N -aryl and N -alkyl isocyanates

Chemical Communications 2026 Open access

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Authors: Davide Castiglione, Alberto Nardi, Margherita Miele, Laura Castoldi, Vittorio Pace
DOI: 10.1039/d5cc06730h
Cited by: 0
References: 62

Abstract

α-Fluoromethyl amides were prepared through the chemoselective nucleophilic addition of fluoromethyl-lithium to isocyanates.

Fields of Study & Subjects

Fluorine in Organic Chemistry Coordination Chemistry and Organometallics Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
22
Pages
6155–6159
Publication date
1 January 2026
Language
EN