A dual-strike strategy against glycolytic and mitochondrial metabolism for potentiated mild photothermal therapy

Chemical Communications 2026

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Authors: Kaiye Wang, Yuting Jia, Xiaohan Liu, Peng Gao, Wei Pan, Na Li, Bo Tang
DOI: 10.1039/d5cc06783a
Cited by: 1
References: 25

Abstract

A dual-strike strategy was developed employing a mitochondria-targeted photothermal agent to concurrently suppress glycolysis and disrupt oxidative phosphorylation. This approach induced ATP depletion and inhibited heat shock protein expression, thereby significantly potentiating the therapeutic efficacy of mild photothermal therapy.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Photodynamic Therapy Research Studies Click Chemistry and Applications

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
11
Pages
3602–3605
Publication date
1 January 2026
Language
EN