A 2nd-generation scalable synthesis of the HIV-1 entry inhibitor CJF-III-288 enabled by photoredox catalysis

Chemical Communications 2026 Open access

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Authors: Jonathan Nadraws, Maithili S. Pokle, Amos B. Smith
DOI: 10.1039/d5cc06802a
Cited by: 0
References: 18

Abstract

The development and optimization of a 2nd-Generation process synthesis for the human immunodeficiency virus-1 entry inhibitor CJF-III-288 bis-trifloroacetate salt 1 is reported. The route eliminates the use of noble metals, decreases the step count nearly by half, and increases the overall yield tenfold.

Fields of Study & Subjects

Radical Photochemical Reactions HIV/AIDS drug development and treatment Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
9
Pages
2981–2985
Publication date
1 January 2026
Language
EN