Consequences of encapsulated vs . covalently attached Pd-NHC amphiphilic polymeric nanocatalysts in bioorthogonal catalysis

Chemical Communications 2026 Open access

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Authors: Lieke de Jonge, Ibai Hazenberg, Harshit Singh, Tessa Loman, A. P. Prakasham, Anja R. A. Palmans
DOI: 10.1039/d5cc06993a
Cited by: 1
References: 32

Abstract

A comparison between novel Pd-NHC (N-heterocyclic carbene) catalysts covalently and non-covalently attached to polymeric nanoparticles reveals that hydrophobic domains in the vicinity of the Pd catalysts aid catalytic activity, and covalent attachment reduces cytotoxicity, opening new avenues to tune bioorthogonal reactivity of TMC-based nanocarriers.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Click Chemistry and Applications N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
13
Pages
4094–4098
Publication date
1 January 2026
Language
EN