Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerization of 1,6-enynes in hexafluoroisopropanol (HFIP)
Abstract
Hydrogen bonding has recently emerged as a powerful yet underexplored tool to enable gold(I) catalysis. Here, we demonstrate that HFIP can directly activate [Au(L)Cl] complexes through hydrogen bonding, in the cycloisomerization of 1,6-enynes under mild conditions without the need for external activators. The influence of ancillary ligands on the catalytic efficiency was systematically examined, revealing that ligand-HFIP interactions play a key role in the activation process. This study provides new insight into hydrogen-bond-assisted gold catalysis and offers a simple strategy for activator-free transformations.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Organometallic Complex Synthesis and Catalysis
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 62
- Issue
- 8
- Pages
- 2664–2667
- Publication date
- 1 January 2026
- Language
- EN