Acid-catalyzed esterification and biotin/fluorescent labeling of glutathione polysulfides based on stability under heating and pH change

Chemical Communications 2026 Open access

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Authors: Masana Yazaki, Yaozhuo Zhang, Lin Zhou, Ryo Morise, Takaaki Akaike, Mieko Arisawa
DOI: 10.1039/d5cc07029e
Cited by: 0
References: 13

Abstract

Glutathione polysulfides are stable in water up to 80 °C and below pH 9. Their carboxyl groups can be efficiently esterified with TMSCl in alcohols. The resulting 3-butyne-1-yl esters allow Cu-catalyzed labeling and can be hydrolyzed by esterases.

Fields of Study & Subjects

Sulfur Compounds in Biology Sulfur-Based Synthesis Techniques Chemical Synthesis and Reactions

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
8
Pages
2668–2671
Publication date
1 January 2026
Language
EN